B-cell-activating factor (BAFF) plays a critical role in B cell survival, and its elevated expression can contribute to the presence of autoreactive B cells, potentially leading to autoimmune conditions like Systemic Lupus Erythematosus (SLE). To deepen our understanding of these mechanisms, GemPharmatech developed a transgenic mouse model featuring human BAFF overexpression. This model offers insights into SLE pathogenesis and serves as a relevant preclinical tool for assessing therapies targeting B cells.